HORDB

ID: hor001461
Uniprot ID: P41854
Protein name: Neuropeptide AF4
Gene name: AFP-1
Organism: Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Family: FARP (FMRFamide related peptide) family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Ascaris (genus), Ascarididae (family), Ascaridoidea (superfamily), Ascaridomorpha (infraorder), Spirurina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: GDVPGVLRF
Length: 9
Propeptide: MVELAAIAVHLFAILCISVSAEIELPDKRAQFDDSFLPYYPSSAFMDSDEAIVAVPSSKPGRYYFDQVGLDAENAMSAREKRGFGDEMSMPGVLRFGKRGMPGVLRFGKRENEKKAVPGVLRFGKRGDVPGVLRFGKRSDMPGVLRFGKRSMPGVLRFGRR
Signal peptide: MVELAAIAVHLFAILCISVSA
Modification: T9 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001461_AF2.pdb

hor001461_ESM.pdb

Mass:	110199	Formula:	C44H70N12O12
Absent amino acids:	ACEHIKMNQSTWY	Common amino acids:	GV
pI:	6.34	Basic residues:	1
Polar residues:	2	Hydrophobic residues:	4
Hydrophobicity:	51.11	Boman Index:	-578
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	107.78
Instability Index:	5168.89	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 7651904
Title: Eight novel FMRFamide-like neuropeptides isolated from the nematode Ascaris suum.